Settings items
The topmost listview of main window contains items, which you can use to set parameters of created installation. These parameters are all saved in configuration file, so you must set all parameters again when you create new installation (eg. you can't copy them between files using CoolSetup directly - but if goes thought clipboard :). All parameters are divided in several parts. Each part is named logically, so you willn't have to look in help (but you can). Now will follow description of each part in chart:
Dealcontains:
Window layoutsettings of background window - visiblity, size, style, title etc.
Installation parametersmain installation paremeters - paths, uninstallation parameters, windows visiblity during installation...
File groupsgroups of files, which are to be installed
Registry actions groupsgroups of registry entries, which are to be installed
Installation typesassembling of final installation types

I think, that if you are so far you are creating installations, I don't have to write here about what all controls are exactly doing. Even though it's not very hard to find out what are they doing, in chapter 2 will you get a detailed guide how to create installation and description of many of those controls...